Completed research projects at the Cellular and Molecular Research Center are as follows.
1.The effect of Nutlin-3 on the expression of P53, P21, PUMA, MDM2 genes as well as its effect on the incidence of apoptosis and cytotoxicity in mesenchymal stem cells obtained from mouse bone marrow
Executor: Dr. Farzad Rajaei
2. Effects of probiotics (combination of Lactobacillus helveticus R0052 and Bifidobacterium longum R0175) on inflammation, apoptosis and memory processes induced by lipopolysaccharide
Executor: Dr. Marjan Nasiri Asl
3.Prevalence of Toxoplasma gondii in sheep and goats slaughtered in Buin Zahra slaughterhouse in Qazvin
Executor: Dr. Mehrzad Sarai
4. Study of intestinal parasites and identification of Giardia and hymenolysis genotypes in food suppliers in Qazvin
Executor: Dr. Mojtaba Shahnazi
5.Evaluation of FOX3a expression and its associated autophagy signaling pathway in Parkinson's disease Model 6-hydroxy dopamine of Wistar rats
Executor: Dr. Shahram Darabi
6. Effect of nicotinic and picolinic acid on the structure and stability of human serum albumin
Executor: Dr. Kourosh Goodarzvand Chegini
7. The effect of omega-3, omega-6 and naringin compounds on the expression and methylation of WIF-1 and WT1 promoters in pancreatic cancer cell lines (Mia Paca II), stomach (AGS) and melanoma (a375)
Executor: Dr. Nematollah Gheibi
8.Evaluation of immunostimulatory effects of Isotretinoin in macrophages infected with Mycobacterium tuberculosis
Executor: Dr. Bahareh Abdolnik Farjam
9. The effect of hydrogen sulfide pretreatment on the prevention of Parkinson's disease in animal model 6-hydroxy dopamine and the possible role of oxidative stress and ATP-sensitive potassium channels
Executor: Dr. Hashem Haghdoost Yazdi
10. Evaluation of the effect of inhibition of ABCB1 gene (MDR-1) in reducing the resistance of cancer cells to chemotherapy agents using CRISPR / Cas technology in drug-resistant ovarian cancer cell line
Executor: Dr. Mohammad Reza Sarukhani
11. Expression and purification of recombinant FGFR2b protein and investigation of its structural changes due to interaction with gallic acid and orange
Executors: Dr. Hossein Piri, Dr. Nematollah Gheibi
12. Evaluation of MIR135a expression in plasma samples of people with pre-diabetic conditions IGT, IFG and diabetes and gestational diabetes in comparison with control groups
Executor: Dr. Mohammad Reza Sarukhani
13.Study of the effect of calprotectin S100A9 and S100A8 protein subunits on the expression and methylation status of OCLN gene promoter in human melanoma A-375 cell line
Executor: Dr. Nematollah Gheibi
14. Relationship between the expression of genes involved in Gemcitabine metabolism such as RRM1, CDA, DCK, SLC29A1 and the amount of microRNAs which control them
Executor: Dr. Farzad Rajaei
15.Evaluation of IL-1B, IFN-γ and IFNG-AS1 gene expression changes in peripheral blood mononuclear cells of patients with schizophrenia and bipolar patients compared with healthy individuals
Moderator: Dr. Seyed Hossein Ghafeleh Bashi
16.Molecular identification of human trichostrongylus in rural residents of Fooman
Executor: Dr. Mehrzad Sarai
17.Evaluation of anticonvulsant and antioxidant effect of hydroalcoholic extract of Zizphora tenuior L. leaves on pentylenetetrazole-induced seizures in mice
Executor: Dr. Hossein Piri
18. The effect of vitexin and quercetin on the production of inflammatory mediators of neutrophils in healthy individuals
Executors: Dr. Marjan Nasiri Asl, Dr. Bahareh Abd Nikfarjam
19. Molecular epidemiology of cutaneous leishmaniasis in carriers, reservoirs and patients of endemic foci .....
Executor: Dr. Mehrzad Sarai
20. Investigation of routine anti-inflammatory effects on neutrophils in normal individuals
Executors: Dr. Bahareh Abd Nikfarjam, Dr. Marjan Nasiri Asl
21.Immunohistochemical expression of p62 protein in Parkinson's disease Model 6-hydroxy dopamine in Wistar rats
Executor: Dr. Shahram Darabi
22. Virolytic oncotherapy with recombinant BTV virus
Executor: Dr. Taghi Naserpour Freer
23. Cloning of mpd and LinA genes in Pseudomonas melloglucida
Executor: Dr. Taghi Naserpour Freer
24. Prevalence of intestinal parasites in rural residents of Takestan (Qazvin province) and Fooman (Gilan province) in 2015
Executor: Dr. Mehrzad Sarai
25. Prevalence of C677T and A1298C polymorphisms of MTHFR gene and its relationship with H19 gene hypomethylation in sperm samples of Iranian men with primary infertility
Executor: Dr. Reza Najafipour
26. Determining the relationship between the expression of genes involved in Gemcitabin metabolism such as SLC29A1, DCK, CDA, RRM1 and the amount of microRNAs controlling them in pancreatic cancer cell lines
Executor: Dr. Farzad Rajaei
27.Evaluation of the role of flunarizine along with B vitamins in the prevention of Parkinson's disease
Executor: Dr. Hashem Haghdoost Yazdi
28. Routine effects on GABAA and BDNF subunit gene expression in temporal lobe seizures in mice
Executor: Dr. Marjan Nasiri Asl
29. Analysis of KRAS mutation and determination of gene expression and immunohistochemical evaluation of HIF1AN protein as a possible prognostic biomarker of human colorectal adenocarcinoma
Executor: Dr. Reza Najafipour
30. Simultaneous diagnosis of pathogenic leptospira and saprophytes
Executor: Dr. Taghi Naserpour Freer
31. Effects of quercetin on gene expression of ionotropic glutamate receptor subunit genes (G1UA1, NR2A, NR2B) and heat shock protein 70 in kainic acid-induced seizures in mice
Executor: Dr. Sahar Moqbelinejad
32. Evaluation of the effects of glass freezing on viability, apoptosis, expression of surface integrins (B1 _ a9) and embryonic development in mice oocytes
Executor: Dr. Farzad Rajaei
33. Investigation of the role of gliben chlamydia along with B vitamins in the prevention of Parkinson's disease in an animal model created by the administration of 6-hydroxy-dopamine
Executor: Dr. Hashem Haghdoost Yazdi
34. Evaluation of the relationship between T + 45G G + 276 T polymorphisms of adiponectin gene and G-238A TNFα gene with insulin resistance and oxidative stress indices in patients with non-alcoholic fatty liver
Executor: Dr. Sahar Moqbelinejad
35. Comparison of TTK, ARMC3 and TPTE gene expression in tissue samples of breast cancer patients with normal tissue
Executor: Dr. Mohammad Reza Sarukhani
36. Preparation of monoclonal antibodies against nmp22 using bladder cancer tissue antigen and evaluation of its properties
Executor: Dr. Mohammad Reza Sarukhani
37. Evaluation of protoscolidal effect of medicinal plants on hydatid cyst and determination of immunomodulatory effect of plants affecting protoscolices on markers of dendritic cell maturation and production of cytokines 18 and IL-12
Executor: Dr. Mojtaba Shahnazi
38. The effect of pre-conditioning with normobaric hyperxia on the progression of Alzheimer's disease in β-amyloid model of Alzheimer's disease
Executor: Dr. Mohammad Hossein Esmaili
39. Introduction of Real time PCR technique in the detection of E. coli genomic DNA impurities in recombinant products
Executor: Dr. Nematollah Gheibi
40. Inhibitory effect of flufenazine, thioridazine and aripiprazole on Toxoplasma gondii cyst formation in mice
Executor: Dr. Bahareh Nik Farjam
41. Evaluation of Toxoplasma infection in the incidence of pentylenetetrazole-induced seizures and its relationship with the frequency of brain cysts in mice
Executor: Dr. Mehrzad Sarai
42. Investigation of routine anti-inflammatory effects on neutrophils in normal individuals
Executor: Dr. Bahareh Abdnik Farjam
43. Toxoplasma infection in the incidence of pentylenetetrazole-induced seizures and its relationship with the frequency of brain cysts in mice
Executor: Dr. Mehrzad Sarai
44. Phenotypic and molecular study of metallobetalactamases and integrons classes 1, 2 and 3 in Pseudomonas aeruginosa isolated from Qazvin and Tehran hospitals
Executor: Dr. Amir Peymani
45. The effect of pretreatment with potassium channel blockers 4-aminopyridine (4-AP) and tetraethyl ammonium (TEA) on the prevention of Parkinson's disease in animal model 6-hydroxy dopamine
Executor: Dr. Hashem Haghdoost Yazdi